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Gingival crevicular fluid is an inflammatory exudate that is derived from the periodontal tissue and can be collected at the orifices or from within the gingival crevice. β-glucuronidase present in the GCF can serve as a marker for primary granule released from polymorphonuclear leukocytes. The presence of this enzyme in GCF can identify and predict probing attachment loss (PAL) in patients with untreated chronic adult periodontitis. All of twenty subjects (14 males & 6 females, mean age 35 years) with sixty sample sites were selected for the present study. Three sample sites (healthy, gingivitis and adult periodontitis) were selected from each individual in different quadrants. The result showed that the level of β-glucuronidases increased as the severity of periodontal disease increased. Thus, the levels of β-glucuronidase (concentration and activity) can be used as a diagnostic marker of periodontal disease.